Serum type I interferon promotes AIM2 inflammasome dysregulation in lupus patients through STAT1 and STAT2
A novel pathway by which serum type-I IFN propagates innate immune dysfunction in SLE via the STAT1-STAT2/AIM2 inflammasome axis in monocytes has been revealed.
Authors
- Jia Xin Chow
- Chak Sing Lau (ORCID: https://orcid.org/0000-0001-6698-8355)
- Chung Sze Or
- Jie Ma (ORCID: https://orcid.org/0000-0002-8934-922X)
- Haijing Wu (ORCID: https://orcid.org/0000-0002-6338-5089)
- Vera Sau Fong Chan
- Jiao Jiang
- Huan Zhu
- Mengqi Yang
Institutions
- Central South University (CN)
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Second Xiangya Hospital of Central South University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1093/rheumatology/keag095
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00