Platelet-rich plasma-derived microRNA let-7a-5p alleviates knee osteoarthritis by regulating macrophage polarization and improving inflammatory microenvironment
PRP reshapes macrophage polarization by regulating the let-7a-5p/MAPK8 axis, thereby improving the inflammatory microenvironment of KOA and providing a potential new therapeutic target for KOA management.
Authors
- Qishan Li
- Xueyuan Sun (ORCID: https://orcid.org/0000-0003-4548-8321)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Mengjie Wang (ORCID: https://orcid.org/0000-0003-3637-4787)
- Dong Wang
- Lin Na
- Yuhang Ma
- Yaochi Nie
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/fimmu.2026.1756467
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00