The psychoactive effects of repeated ketamine infusions and their mechanistic role in the treatment of alcohol use disorder: Secondary analysis of a randomised controlled trial
People with alcohol use disorder experience alterations in consciousness from 0.8 mg/kg intravenous ketamine administration. Ketamine's effects appear to be broadly consistent across three repeated infusions. Ketamine-related reductions in alcohol consumption do not appear to be mediated by the acute psychoactive effects of ketamine.
Authors
- Celia Janet Ann Morgan
- Ananya Sarma
- Meryem Grabski (ORCID: https://orcid.org/0000-0001-6364-5269)
- Anne Lingford‐Hughes (ORCID: https://orcid.org/0000-0003-4512-3453)
- Joshua Shotton
- Lorna Hardy
- Will Lawn
- Bethan Marsh
- Merve Mollaahmetoglu
- Shamhethan Bhaskaran
- H. Val Curran
- Cassie Bloy
Institutions
- Goethe University Frankfurt (DE)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- University of Exeter (GB)
- Luton and Dunstable University Hospital NHS Foundation Trust (GB)
- Hammersmith Hospital (GB)
- Language Science (South Korea) (KR)
- University College London (GB)
- Frankfurt University of Applied Sciences (DE)
- University of Sheffield (GB)
Publication Details
- Journal
- Addiction
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1111/add.70320
- Citations
- 1
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 32.57