Ion channel gene signature for diagnosis and antifibrotic therapy in liver fibrosis
This study demonstrates that AQP1, GJA1, and KCNN2 are closely associated with LF progression and immune remodeling. The consistent upregulation of GJA1, together with the identification of candidate drug interactions, provides potential avenues for biomarker development and therapeutic repurposing in LF.
Authors
- Jianguo Li (ORCID: https://orcid.org/0009-0009-2588-730X)
- Yun Li
- Fusheng Qin
- Dongkui Chen
- Duoer Shen
Institutions
- Fourth Hospital of Changsha (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1186/s12967-026-07856-1
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00