Connecting systemic inflammation to prognosis in neuroendocrine neoplasms: a biomarker-based approach
In summary, this study identifies SII, NLR and PLR as accessible, reliable, and cost-effective biomarkers with prognostic value in NENs. Thus, integrating these indices with established clinicopathological features may improve risk stratification and inform personalized management. Nonetheless, validation in larger, prospective cohorts is necessary to substantiate these findings.
Authors
- Diana Derewicz (ORCID: https://orcid.org/0009-0002-7058-0963)
- Andreea Ilieșiu
- Ioana Maria Lambrescu (ORCID: https://orcid.org/0000-0003-2040-8671)
- Mariana Costache
- Vanda Roxana Nimigean
- Dana Antonia Țǎpoi
- Luiza Elena Tomescu
- Ancuța-Augustina Gheorghişan-Gǎlǎțeanu
Institutions
- Synlab Czech (Czechia) (CZ)
- Carol Davila University of Medicine and Pharmacy (RO)
- Avila University (US)
- Victor (Japan) (JP)
- Spitalului Clinic de Urgență pentru Copii Maria Sklodowska Curie (RO)
- National Institute of Pathology (IN)
- Emergency University (US)
- Institutul Național de Endocrinologie C.I. Parhon (RO)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/fmed.2026.1728726
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00