Gut microbiome-driven modulation of the tumor immune microenvironment optimizes dual checkpoint blockade in advanced non-small-cell lung cancer

Gut microbiota diversity and SCFA-producing bacteria are associated with improved efficacy of I-N. Baseline gut microbiota diversity may help identify patients who are more likely to have improved outcomes with I-N plus chemotherapy than with I-N alone. These findings highlight the potential of gut microbiota as a novel biomarker for dual checkpoint blockade in NSCLC may contribute to advancing personalized medicine.

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Publication Details

Journal
ESMO Open
Published
2026-02-16
DOI
https://doi.org/10.1016/j.esmoop.2026.106077
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Gut microbiome-driven modulation of the tumor immune microenvironment optimizes dual checkpoint blockade in advanced non-small-cell lung cancer

K. Takayama, R. Sawada, A. Yoshimura, S. Kumagai et al.
ESMO Open
Gut microbiota and health
article

Gut microbiome-driven modulation of the tumor immune microenvironment optimizes dual checkpoint blockade in advanced non-small-cell lung cancer

K. Takayama, R. Sawada, A. Yoshimura, S. Kumagai, A. Fukuda, T. Takagi, A. Okada, T. Harada, N. Nishioka, Y. Katayama, H. Kawachi, R. Inoue, S. Shiotsu, S. Tokuda, Y. Takemura, Y. Chihara, T. Yamada, S. Koyama, M. Iwasaku
article en

Abstract

Gut microbiota diversity and SCFA-producing bacteria are associated with improved efficacy of I-N. Baseline gut microbiota diversity may help identify patients who are more likely to have improved outcomes with I-N plus chemotherapy than with I-N alone. These findings highlight the potential of gut microbiota as a novel biomarker for dual checkpoint blockade in NSCLC may contribute to advancing personalized medicine.

ESMO OpenVol. 11(3)
Setsunan University (JP), Kyoto Prefectural University of Medicine (JP), National Cancer Centre Japan (JP), Otsu Municipal Hospital (JP), Fukuyama City Hospital (JP), Saiseikai Suita Hospital (JP), Kyoto first Red Cross hospital (JP), Matsushita Memorial Hospital (JP), Japanese Red Cross Society Kyoto Daini Hospital (JP), National Cancer Research Institute (GB)
Good health and well-being
Openalex Percentile: Top 55%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
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Gut microbiome-driven modulation of the tumor immune microenvironment optimizes dual checkpoint blockade in advanced non-small-cell lung cancer — K. Takayama, R. Sawada, et al. · ESMO Open (2026) | TGRS Research Map | TGRS