Comparative risk of <i>Clostridioides difficile</i> infection in patients with Crohn’s disease receiving ustekinumab versus anti-TNF therapy: a retrospective cohort study
In this real-world cohort, treatment with UST was not associated with a significantly higher risk of CDI or <i>C. difficile</i> positivity compared to anti-TNF therapy. The consistent direction of point estimates, suggesting a potential risk reduction especially in biologic-naïve patients, remains exploratory and warrants further investigation in larger studies.
Authors
- J Deng
- Jiahui Huang (ORCID: https://orcid.org/0009-0000-7922-2084)
- X Peng
- J Yao
- M Zhi
- M Zhang
- Qi Zhang
- Tao Liu
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Therapeutic Advances in Gastroenterology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1177/17562848261421706
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00