Shuxuening injection improves ventricular remodeling after myocardial infarction by indirectly promoting macrophage-mediated angiogenesis and lymphangiogenesis
SXNI activates macrophages to secrete VEGFs, such as VEGF-A and VEGF-C, which in turn activate the VEGFR2 and VEGFR3 signaling pathways in endothelial cells and lymphatic endothelial cells, thereby promoting angiogenesis and lymphangiogenesis and ameliorating ventricular remodeling. The key active ingredients in SXNI may be ginkgolide A, ginkgolide B, rutin and quercetin 3-neohesperidoside. This work provides valuable clinical evidence supporting its use in MI patient treatment.
Authors
- Yajuan Zheng
- Xiaoshuai Zhang (ORCID: https://orcid.org/0000-0001-5405-0802)
- Liuqing Yang (ORCID: https://orcid.org/0000-0002-6518-474X)
- Jinfa Tang
- Hui Zhang (ORCID: https://orcid.org/0000-0003-1950-3591)
- Pan Wang (ORCID: https://orcid.org/0000-0001-6034-4639)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Yali Wu
- Mingliang Zhang
- Xiaofei Chen
- Weixia Li
- Yingjie Cao
- Yuhui Li
- Bin Wang
- Xiaoyan Wang
- Shiting Wei
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1186/s13020-026-01352-w
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00