Evidence for Nonlinear Behavior of Propofol Pharmacodynamics Using Temporal Analysis of Bispectral Index and Modulation of the Frontal Alpha Oscillation
These findings suggest that current models are inadequate in explaining the dose-effect relationship of propofol's anesthetic properties. Specifically, linear models are unable to capture the nonlinear dynamics of brain activity and their response to disturbances, such as a brief period of burst suppression.
Authors
- Ricardo Gutiérrez (ORCID: https://orcid.org/0000-0001-6988-0251)
- P. Sepúlveda (ORCID: https://orcid.org/0000-0001-9810-7639)
- S Baloian
- Ignacio Barra
Institutions
- Universidad de Santiago de Chile (CL)
- Hospital Base (CL)
- University of Chile (CL)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1213/ane.0000000000007949
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00