Estimation of Transpulmonary Driving Pressure, Strain, and Lung-Specific Elastance Using Volumetric Methods in Invasively Ventilated Children—A Feasibility Study

Despite technical limitations, it appears possible to estimate DPTP, strain, and k by integrating the PEEP-step and NMBW methods. Validation against the gold standard esophageal pressure manometry is warranted.

Authors

Martin C. J. Kneyber (ORCID: https://orcid.org/0000-0002-6008-3376)
Dinesh Chirla (ORCID: https://orcid.org/0000-0002-5939-4206)
F. A. Shaikh
Shekhar Venkatraman
Venkat Sandeep Reddy
Nandan Kalkunte Venugopal
Karthik Narayanan Ramaswamy
Monesh Kethineni Bhaskaran

Institutions

University Medical Center Groningen (NL)
University of Groningen (NL)
University of Pittsburgh (US)
Rainbow Children's Hospital (IN)

Publication Details

Journal: Pediatric Critical Care Medicine
Published: 2026-02-16
DOI: https://doi.org/10.1097/pcc.0000000000003905
Primary Topic: Respiratory Support and Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

Estimation of Transpulmonary Driving Pressure, Strain, and Lung-Specific Elastance Using Volumetric Methods in Invasively Ventilated Children—A Feasibility Study

Martin C. J. Kneyber, Dinesh Chirla, F. A. Shaikh, Shekhar Venkatraman et al.

Feb 16, 2026

Pediatric Critical Care Medicine

Respiratory Support and Mechanisms

article

Estimation of Transpulmonary Driving Pressure, Strain, and Lung-Specific Elastance Using Volumetric Methods in Invasively Ventilated Children—A Feasibility Study

Martin C. J. Kneyber, Dinesh Chirla, F. A. Shaikh, Shekhar Venkatraman, Venkat Sandeep Reddy, Nandan Kalkunte Venugopal, Karthik Narayanan Ramaswamy, Monesh Kethineni Bhaskaran

February 16, 2026article en

Abstract

Despite technical limitations, it appears possible to estimate DPTP, strain, and k by integrating the PEEP-step and NMBW methods. Validation against the gold standard esophageal pressure manometry is warranted.

Pediatric Critical Care Medicine

University Medical Center Groningen (NL), University of Groningen (NL), University of Pittsburgh (US), Rainbow Children's Hospital (IN)

Openalex Percentile: Top 55%

Respiratory Support and Mechanisms

DOI Open Access PDF OpenAlex

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Estimation of Transpulmonary Driving Pressure, Strain, and Lung-Specific Elastance Using Volumetric Methods in Invasively Ventilated Children—A Feasibility Study — Martin C. J. Kneyber, Dinesh Chirla, et al. · Pediatric Critical Care Medicine (2026) | TGRS Research Map | TGRS