Age- and sex-specific reference intervals for 11-oxygenated androgens from infancy throughout childhood and adulthood
Established age-, sex-, and puberty-dependent RIs support the clinical interpretation of 11-OA measurements in disorders characterized by androgen excess. The differences in the regulation of classical androgens and 11-OAs during minipuberty suggest that the transient increase in androgens during the first months of life is most likely due to activation of the hypothalamic-pituitary-gonadal axis.
Authors
- Wieland Kiess
- Alexander Gaudl (ORCID: https://orcid.org/0000-0002-7197-3868)
- Robert Zeidler
- Ronald Biemann (ORCID: https://orcid.org/0000-0002-0820-8231)
- Ronny Baber
- Berend Isermann (ORCID: https://orcid.org/0000-0003-0714-6160)
- Friederike Wagner
- Uta Ceglarek
- K. Wirkner
- Mandy Vogel
- Jürgen Kratzsch
Institutions
- Leipzig University of Applied Sciences (DE)
- University Hospital Leipzig (DE)
- German Centre for Cardiovascular Research (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1515/cclm-2025-1440
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00