Attenuated hemodynamic response to adjunct vasopressin in obese septic shock patients: a physiological or dose-dependent effect?
In septic shock patients, obesity is associated with increased NE requirement after AVP initiation, in contrast to the reduction observed in normal weight patients. Obesity-related resistance to AVP may be driven by intrinsic physiological factors rather than insufficient dosing.
Authors
- Peter Pickkers
- Max Melchers
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Ziekenhuis Gelderse Vallei (NL)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Critical Care
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1186/s13054-026-05871-8
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Radboud Universiteit
- Radboud Universitair Medisch Centrum
- AOP Orphan