Fast Real-Time Assessment of Combination Therapies in Immuno-ONcology in patients with advanced non-small-cell lung cancer (FRACTION-Lung)
Despite limited efficacy, the innovative adaptive trial design allowed rapid evaluation of multiple regimens, which may inform future trials.
Authors
- DM Greenawalt
- S.A. Laurie
- J.F. Gainor
- D.R. Camidge
- H. Borghaei
- K. L. He
- R.A. Juergens
- A. Spira
- A.J. Schoenfeld
- Q. Chu
- P.M. Forde
- R. Zinner
- A. Santoro
- S. Gettinger
- A. Gurpide
- M. Cerra
- T. Spires
- R. Govindan
- I. Rapoport
- D.R. Spigel
Institutions
- Alberta Health Services (CA)
- Memorial Sloan Kettering Cancer Center (US)
- Humanitas University (IT)
- University of Ottawa (CA)
- Trinity College (CA)
- Washington University in St. Louis (US)
- Trinity College Dublin (IE)
- Juravinski Cancer Centre (CA)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Ottawa Hospital (CA)
- Markey Cancer Center (US)
- Yale Cancer Center (US)
- Massachusetts General Hospital (US)
- Bristol-Myers Squibb (United States) (US)
- Sarah Cannon (US)
- Virginia Cancer Specialists (US)
- Temple University Health System (US)
- Clinica Universidad de Navarra (ES)
- IRCCS Humanitas Research Hospital (IT)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1016/j.esmoop.2026.106078
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00