Refractory anti–NMDA receptor encephalitis driven by a contralateral ovarian teratoma following unilateral oophorectomy: a case report

This case demonstrates that postoperative residual or contralateral ovarian teratomas can drive persistent anti-NMDAR encephalitis despite immunotherapy. Repeat imaging should be strongly considered in refractory cases, and complete tumor resection remains essential to interrupt the autoimmune process. Early multidisciplinary collaboration between gynecology, neurology, and intensive care teams is crucial to optimize neurological outcomes.

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Publication Details

Journal
International Journal of Surgery Case Reports
Published
2026-02-16
DOI
https://doi.org/10.1097/rc9.0000000000000292
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
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article

Refractory anti–NMDA receptor encephalitis driven by a contralateral ovarian teratoma following unilateral oophorectomy: a case report

Lisa Novianti, Rabbania Hiksas, Patricia Alika Kurniawan, Intan Indah Permatasari et al.
International Journal of Surgery Case Reports
Autoimmune Neurological Disorders and Treatments
article

Refractory anti–NMDA receptor encephalitis driven by a contralateral ovarian teratoma following unilateral oophorectomy: a case report

Lisa Novianti, Rabbania Hiksas, Patricia Alika Kurniawan, Intan Indah Permatasari, Thalia Amila Elsiyana, Achmad Kemal Harzif
article en

Abstract

This case demonstrates that postoperative residual or contralateral ovarian teratomas can drive persistent anti-NMDAR encephalitis despite immunotherapy. Repeat imaging should be strongly considered in refractory cases, and complete tumor resection remains essential to interrupt the autoimmune process. Early multidisciplinary collaboration between gynecology, neurology, and intensive care teams is crucial to optimize neurological outcomes.

International Journal of Surgery Case ReportsVol. 138(3)
University of Indonesia (ID), Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
Good health and well-being
Openalex Percentile: Top 58%
Autoimmune Neurological Disorders and Treatments
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