Real-World Efficacy of IL-23 Inhibitors in Psoriasis Affecting High-Impact Areas: Indirect Comparison of Tildrakizumab 200 mg, Risankizumab, and Guselkumab—IL PSO (Italian Landscape Psoriasis)
In real-world clinical practice, IL-23p19 inhibitors provide high and sustained efficacy in psoriasis affecting high-impact sites. Risankizumab offers faster and deeper responses, while tildrakizumab 200 mg represents an effective long-term option, particularly in patients with higher BMI or more treatment-resistant disease. These findings support a personalized approach to biologic selection based on disease localization, patient characteristics, and therapeutic goals.
Authors
- Marco Campoli (ORCID: https://orcid.org/0000-0002-3843-0108)
- Martina Maurelli (ORCID: https://orcid.org/0000-0001-7492-8010)
- Marco Manfredini (ORCID: https://orcid.org/0000-0003-3601-655X)
- Helena Gioacchini
- Massimiliano Nicolini
- Claudia Lasagni (ORCID: https://orcid.org/0000-0002-0370-6602)
- Martina Dragotto (ORCID: https://orcid.org/0009-0006-9441-3923)
- Annunziata Raimondo (ORCID: https://orcid.org/0000-0002-0849-715X)
- Aldo Cuccia (ORCID: https://orcid.org/0000-0002-0276-1554)
- Nicole Macagno (ORCID: https://orcid.org/0000-0002-0097-2139)
- Santo Raffaele Mercuri (ORCID: https://orcid.org/0000-0002-9175-4574)
- A Campanati
- Valentina Dini (ORCID: https://orcid.org/0000-0002-8537-1999)
- Luca Potestio (ORCID: https://orcid.org/0000-0001-5940-0592)
- Franco Cona
- Pietro Morrone
- Nicola Zerbinati (ORCID: https://orcid.org/0000-0003-2177-9677)
- A. Rossi
- Francesca Maria Gaiani (ORCID: https://orcid.org/0009-0003-7613-4451)
- Claudio Guarneri
- Giulia Rech
- E. Trovato
- Diego Orsini
- Anna Scuderi
- Davide Strippoli
- Andrea Altomare
- Marco ROMANELLI
- Andrea Carugno
- Claudia Giofre’
- Gianluca Pagnanelli
- Andrea Michelerio
- Clara De Simone
- Carmen Fiorella
- Francesco Messina
- Alessandra Capo
- Alessandro Borghi
- Franco Rongioletti
- Antonio Costanzo
- Nicoletta Bernardini
- Luca Mastorino
- Alexandra Brunasso Vannetti
- Carlo Carrera
- Giancarlo Lazzaro Danzuso
- Giampiero Girolomoni
- Francesca Satolli
- Vito Di Lernia
- Federico Bardazzi
- Tommaso Bianchelli
- Viviana Lora
- Francesco Loconsole
- Maria Concetta Fargnoli
- Piergiorgio Malagoli
- for the Italian Landscape Group
- Giovanni Marco D’Agostino
Institutions
- University of Siena (IT)
- University of Insubria (IT)
- University of Verona (IT)
- University of Modena and Reggio Emilia (IT)
- Marche Polytechnic University (IT)
- University of Parma (IT)
- Ospedale Santa Chiara (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- IRCCS Policlinico San Donato (IT)
- Istituto Dermopatico dell'Immacolata (IT)
- San Gallicano Hospital (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Dermatology and Therapy
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1007/s13555-026-01662-9
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00