Differential Pathophysiological Drivers of Susceptibility to Type 2 Diabetes and Metabolic Dysfunction–Associated Steatotic Liver Disease: Ethnic Differences in Insulin Dynamics, Whole‐Body Fat Metabolism, and Organ‐Specific Lipid Deposition

Dysregulated fat metabolism in adipose tissue/liver may increase serum fatty acids and triglyceride concentrations exposing non-adipose tissues to increased lipid. Differential T2D susceptibility likely reflects diverse but ethnic group-specific metabolic phenotypes representing genetic and environmentally mediated pathophysiological traits, consistent with the "palette" model of T2D.

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Journal
Obesity Reviews
Published
2026-02-16
DOI
https://doi.org/10.1111/obr.70104
Primary Topic
Diabetes, Cardiovascular Risks, and Lipoproteins
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article
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article

Differential Pathophysiological Drivers of Susceptibility to Type 2 Diabetes and Metabolic Dysfunction–Associated Steatotic Liver Disease: Ethnic Differences in Insulin Dynamics, Whole‐Body Fat Metabolism, and Organ‐Specific Lipid Deposition

Goff Louise, Daniel James Cuthbertson, W. G. Martin, Uazman Alam et al.
Obesity Reviews
Diabetes, Cardiovascular Risks, and Lipoproteins
article

Differential Pathophysiological Drivers of Susceptibility to Type 2 Diabetes and Metabolic Dysfunction–Associated Steatotic Liver Disease: Ethnic Differences in Insulin Dynamics, Whole‐Body Fat Metabolism, and Organ‐Specific Lipid Deposition

Goff Louise, Daniel James Cuthbertson, W. G. Martin, Uazman Alam, Alex E. Henney, A. Margot Umpleby, Barbara A. Fielding
article en

Abstract

Dysregulated fat metabolism in adipose tissue/liver may increase serum fatty acids and triglyceride concentrations exposing non-adipose tissues to increased lipid. Differential T2D susceptibility likely reflects diverse but ethnic group-specific metabolic phenotypes representing genetic and environmentally mediated pathophysiological traits, consistent with the "palette" model of T2D.

Obesity Reviews
University of Liverpool (GB), King's College London (GB), Aintree University Hospitals NHS Foundation Trust (GB), Leicester General Hospital (GB), Nutrition Sciences (Belgium) (BE), King's College Hospital (GB)
Good health and well-being
Openalex Percentile: Top 56%
Diabetes, Cardiovascular Risks, and Lipoproteins
DOIOpen Access PDFOpenAlex
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Differential Pathophysiological Drivers of Susceptibility to Type 2 Diabetes and Metabolic Dysfunction–Associated Steatotic Liver Disease: Ethnic Differences in Insulin Dynamics, Whole‐Body Fat Metabolism, and Organ‐Specific Lipid Deposition — Goff Louise, Daniel James Cuthbertson, et al. · Obesity Reviews (2026) | TGRS Research Map | TGRS