Efficacy and evaluation of dose-response relationship of selective internal radiation therapy for the management of liver metastases in neuroendocrine neoplasia
In a prospective study of heavily pretreated patients, we have demonstrated clinical efficacy of SIRT for the management of liver metastases secondary to NENs. A tumour dose-response relationship was demonstrated and a threshold tumour dose for survival outcome. This work lends prospective evidence for personalised dosimetry in NENs.
Authors
- Florian Wernig (ORCID: https://orcid.org/0000-0001-5914-9318)
- Chloe D. Bowen (ORCID: https://orcid.org/0000-0003-2929-7883)
- R. A. Thomas (ORCID: https://orcid.org/0000-0003-4467-4827)
- Neva Patel (ORCID: https://orcid.org/0000-0001-8954-7958)
- Paul Tait (ORCID: https://orcid.org/0009-0009-2783-8069)
- K. S. Nijran
- Caroline Ward (ORCID: https://orcid.org/0009-0006-3256-4515)
- Laura J. Perry
- Hooshang Izadi
- Ali Alsafi
- Priten Khagram
- Nikolaos Doumanoglou
- Rohini Sharma
- Tahir Shah
- Maria Martinez
- Joanne Evans
- Mark Bray-Parry
Institutions
- Oxford Brookes University (GB)
- Imperial College Healthcare NHS Trust (GB)
- London Clinic (GB)
- Hammersmith Hospital (GB)
- NIHR Birmingham Liver Biomedical Research Unit (GB)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1007/s00259-026-07762-0
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Imperial College London
- NIHR Imperial Biomedical Research Centre