Network pharmacology, machine learning, and experiments uncover β-sitosterol targeting HSP90AA1 in medicinal-edible black soybean against aging
This work reveals that β-sitosterol, a core component of black soybean, combats skin photoaging by targeting the HSP90AA1-mediated stress adaptation and regulating the p53-BCL2 signaling axis. These findings provide a molecular basis for the application of this medicinal-edible substance in anti-aging interventions.
Authors
- Dan Luo (ORCID: https://orcid.org/0000-0002-8202-7420)
- Jingyi Yang (ORCID: https://orcid.org/0000-0002-3307-0158)
- Min Wei (ORCID: https://orcid.org/0009-0005-0173-2435)
- Yuting Yang
- Yuanyuan Jia
- Qian Chen
Institutions
- Jiangsu University (CN)
- First People's Hospital of Kunshan (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/fmed.2026.1749856
- Primary Topic
- Phytoestrogen effects and research
- Type
- article
- Field-Weighted Citation Impact
- 0.00