The endothelial plasma membrane lipidome and its remodeling under hyperglycemia: an exploratory study
The hyperglycemia-induced alterations provide insights into the endothelial membrane lipid environment and the biophysical dynamics that are likely to deregulate protein-lipid interactions involved in sugar and lipid metabolism. The high amount of Chol found in our work serves as the basis for future <i>in silico</i> simulations crucial for drug design and drug response evaluation.
Authors
- Yahya Sohrabi (ORCID: https://orcid.org/0000-0001-5268-238X)
- Bruno Antonny (ORCID: https://orcid.org/0000-0002-9166-8668)
- Ana Rita Dias Araújo (ORCID: https://orcid.org/0000-0003-3729-747X)
- Merle Leffers
- Alisa Rudnitskaya (ORCID: https://orcid.org/0000-0002-7963-3892)
- Lorena Diaz-Sanchez
- Irundika H. K. Dias
- Ana Reis
- Rui Vitorino
Institutions
- Aston University (GB)
- Aston Medical (France) (FR)
- University Hospital Münster (DE)
- Institute for Biomedicine (IT)
- Rede de Química e Tecnologia (PT)
- Institut de Pharmacologie Moléculaire et Cellulaire (FR)
- University of Aveiro (PT)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/fmolb.2025.1701375
- Primary Topic
- Lipid Membrane Structure and Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade de Aveiro
- Joint Programming Initiative on Antimicrobial Resistance
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Westfälische Wilhelms-Universität Münster
- Ministério da Ciência, Tecnologia e Ensino Superior
- Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro
- Fundação para a Ciência e a Tecnologia