A Network Pharmacology Prediction and Molecular Docking-Based Strategy to Explore the Potential Pharmacological Mechanism of Vitexin for Cerebral Ischemia-Reperfusion Injury

Through the application of network pharmacology and molecular docking techniques, this study confirmed that Vitexin could strongly bind to the MAPK8 protein, thereby inhibiting its expression and blocking the MAPK signaling pathway to effectively alleviate CIRI.

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Publication Details

Journal
Shock
Published
2025-12-11
DOI
https://doi.org/10.1097/shk.0000000000002775
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

A Network Pharmacology Prediction and Molecular Docking-Based Strategy to Explore the Potential Pharmacological Mechanism of Vitexin for Cerebral Ischemia-Reperfusion Injury

Wen Zhang, Shouzhi Fu, Luyu Yang, Wankang Dian
Shock
Neuroinflammation and Neurodegeneration Mechanisms
article

A Network Pharmacology Prediction and Molecular Docking-Based Strategy to Explore the Potential Pharmacological Mechanism of Vitexin for Cerebral Ischemia-Reperfusion Injury

Wen Zhang, Shouzhi Fu, Luyu Yang, Wankang Dian
article en

Abstract

Through the application of network pharmacology and molecular docking techniques, this study confirmed that Vitexin could strongly bind to the MAPK8 protein, thereby inhibiting its expression and blocking the MAPK signaling pathway to effectively alleviate CIRI.

ShockVol. 65(3)
Wuhan Third Hospital (CN)
Good health and well-being
Openalex Percentile: Top 33%
Neuroinflammation and Neurodegeneration Mechanisms
DOISourceOpenAlex
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A Network Pharmacology Prediction and Molecular Docking-Based Strategy to Explore the Potential Pharmacological Mechanism of Vitexin for Cerebral Ischemia-Reperfusion Injury — Wen Zhang, Shouzhi Fu, et al. · Shock (2025) | TGRS Research Map | TGRS