Redox modulation contributes to the antidepressant-like and neuroprotective effects of 7-chloro-4-(phenylselanyl)quinoline in an Alzheimer’s disease model
By restoring redox homeostasis and attenuating neuroinflammatory responses, 4-PSQ effectively counteracted behavioral and biochemical disruptions associated with Aβ toxicity. These findings support 4-PSQ as a promising selenium-based therapeutic candidate targeting redox-driven features of AD, including comorbid depression and cognitive decline.
Authors
- Ariana Silveira Lima
- Renata L. de Oliveira
- Caroline Brandão Quines (ORCID: https://orcid.org/0000-0002-3818-1690)
- Ane G. Vogt
- Guilherme T. Voss
- Janice Luehring Giongo (ORCID: https://orcid.org/0000-0002-2199-0838)
- Eduarda Monteiro Fidélis (ORCID: https://orcid.org/0000-0001-7890-1659)
- Diego Filipe Cordeiro Alves (ORCID: https://orcid.org/0000-0003-3461-2657)
- Lucielli Savegnago (ORCID: https://orcid.org/0000-0003-0494-5610)
- Mikaela P. Pinz (ORCID: https://orcid.org/0000-0003-1153-4916)
- Simone Pinton (ORCID: https://orcid.org/0000-0001-6630-7329)
- Victor Dos S. Barboza
- Rodrigo De A. Vaucher
- Karline Da C. Rodrigues
- Cristiane Luchese
Institutions
- Universidade Federal de Pelotas (BR)
- Universidade de São Paulo (BR)
- Universidade Federal do Pampa (BR)
Publication Details
- Journal
- Redox Report
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1080/13510002.2026.2626641
- Citations
- 1
- Primary Topic
- Organoselenium and organotellurium chemistry
- Type
- article
- Field-Weighted Citation Impact
- 33.63