The association between anti-acid use and tyrosine kinase inhibitor–induced hepatotoxicity

The impact of coadministration of TKIs with antacids on hepatotoxicity varies depending on the specific TKI and its pharmacokinetic characteristics. These interactions highlight the need for careful evaluation and monitoring in clinical practice.

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Publication Details

Journal
Journal of Oncology Pharmacy Practice
Published
2026-02-16
DOI
https://doi.org/10.1177/10781552261422378
Primary Topic
Drug-Induced Hepatotoxicity and Protection
Type
article
Field-Weighted Citation Impact
0.00
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article

The association between anti-acid use and tyrosine kinase inhibitor–induced hepatotoxicity

Hamed Ghiami, Mohammadsalman Parsapour, Omid Arasteh, Navid Omidkhoda
Journal of Oncology Pharmacy Practice
Drug-Induced Hepatotoxicity and Protection
article

The association between anti-acid use and tyrosine kinase inhibitor–induced hepatotoxicity

Hamed Ghiami, Mohammadsalman Parsapour, Omid Arasteh, Navid Omidkhoda
article en

Abstract

The impact of coadministration of TKIs with antacids on hepatotoxicity varies depending on the specific TKI and its pharmacokinetic characteristics. These interactions highlight the need for careful evaluation and monitoring in clinical practice.

Journal of Oncology Pharmacy Practice
Islamic Azad University, Tehran (IR), Mashhad University of Medical Sciences (IR)
Good health and well-being
Openalex Percentile: Top 53%
Drug-Induced Hepatotoxicity and Protection
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The association between anti-acid use and tyrosine kinase inhibitor–induced hepatotoxicity — Hamed Ghiami, Mohammadsalman Parsapour, et al. · Journal of Oncology Pharmacy Practice (2026) | TGRS Research Map | TGRS