Treatment outcomes for oropharyngeal cancer: findings from an institutional study

This study demonstrates excellent outcomes for HPV-positive OPSCC, consistent with RTOG 0129 and 1016 trials. RCT, particularly with 3-weekly cisplatin, was associated with superior survival outcomes, with an absolute 15% difference in 5-year OS in HPV-positive patients compared with weekly cisplatin. RCT remains the standard of care, while HPV-negative disease continues to pose a major therapeutic challenge.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-02-16
DOI
https://doi.org/10.3389/fonc.2026.1720966
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Treatment outcomes for oropharyngeal cancer: findings from an institutional study

Sameh Geha, C Wang, Mathieu Belzile, Jérôme Costisella et al.
Frontiers in Oncology
Head and Neck Cancer Studies
article

Treatment outcomes for oropharyngeal cancer: findings from an institutional study

Sameh Geha, C Wang, Mathieu Belzile, Jérôme Costisella, Isabelle Gauthier, Ayman Jafar Oweida, Benoit Emond-Guilbert, Pierre-Hugues Fortier
article en

Abstract

This study demonstrates excellent outcomes for HPV-positive OPSCC, consistent with RTOG 0129 and 1016 trials. RCT, particularly with 3-weekly cisplatin, was associated with superior survival outcomes, with an absolute 15% difference in 5-year OS in HPV-positive patients compared with weekly cisplatin. RCT remains the standard of care, while HPV-negative disease continues to pose a major therapeutic challenge.

Frontiers in OncologyVol. 16
Université de Sherbrooke (CA), Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean (CA)
Good health and well-being
Openalex Percentile: Top 54%
Head and Neck Cancer Studies
DOIOpen Access PDFOpenAlex
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