Lipidomic profiles associated with treatment related hepatotoxicity in children with acute lymphoblastic leukemia
We identified plasma lipid profiles, characterized by elevated PCs and SMs with reduced triglycerides, associated with the incidence of TAH in children with ALL. Similar patterns have been linked to metabolic liver disease in adults and children. These findings suggest lipid dysregulation may contribute to TAH susceptibility and highlight candidate biomarkers for future validation in larger cohorts.
Authors
- Karen R. Rabin (ORCID: https://orcid.org/0000-0002-4081-8195)
- Steven D. Mittelman (ORCID: https://orcid.org/0000-0003-2867-1298)
- Baojiang Chen (ORCID: https://orcid.org/0000-0002-9683-9390)
- John P. Woodhouse
- Olga A. Taylor
- Jeremy M. Schraw (ORCID: https://orcid.org/0000-0002-6674-9562)
- Emily J. Mason (ORCID: https://orcid.org/0000-0001-8120-2138)
- Etan Orgel
- Joanna S. Yi (ORCID: https://orcid.org/0000-0002-0914-8728)
- Philip J. Lupo
- Michael E. Scheurer
- M. Monica Gramatges
- Kevin A. Williams
- Melissa B. Harrell
- Van Huynh
- Austin Brown
Institutions
- Children's Hospital of Orange County (US)
- Children's Hospital of Los Angeles (US)
- Emory University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- Children's Cancer Center (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Supportive Care in Cancer
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1007/s00520-026-10414-6
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- National Cancer Institute