Comparative cardioprotective effects of Kuanxiong Aerosol and its individual components in a rat model of acute myocardial infarction

KXA's cardioprotection stems from the synergistic action of its components targeting ischemia, fibrosis, inflammation, and cardiac dysfunction. This study provides evidence supporting the cardioprotective potential of low-dose, multi-component KXA, indicating that such balanced formulations may offer broader benefits than high-dose or single-agent approaches. Further research is needed to elucidate the molecular mechanisms and refine the formulation for clinical translation.

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Publication Details

Journal
Pharmaceutical Biology
Published
2026-02-15
DOI
https://doi.org/10.1080/13880209.2026.2626099
Primary Topic
Cardiac Fibrosis and Remodeling
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparative cardioprotective effects of Kuanxiong Aerosol and its individual components in a rat model of acute myocardial infarction

Xiaokang Peng, Yuan-hang Zheng, Xiaojing Fan, Kai Qian et al.
Pharmaceutical Biology
Cardiac Fibrosis and Remodeling
article

Comparative cardioprotective effects of Kuanxiong Aerosol and its individual components in a rat model of acute myocardial infarction

Xiaokang Peng, Yuan-hang Zheng, Xiaojing Fan, Kai Qian, Yefeng Chen, Yang-yang Zhu, Tao Yang, Yu Tang, Jin-ting Zhang, Meng-meng Xu, Yi Luo
article en

Abstract

KXA's cardioprotection stems from the synergistic action of its components targeting ischemia, fibrosis, inflammation, and cardiac dysfunction. This study provides evidence supporting the cardioprotective potential of low-dose, multi-component KXA, indicating that such balanced formulations may offer broader benefits than high-dose or single-agent approaches. Further research is needed to elucidate the molecular mechanisms and refine the formulation for clinical translation.

Pharmaceutical BiologyVol. 64(1)
Zhejiang Pharmaceutical College (CN), Zhejiang University (CN)
Good health and well-being
Openalex Percentile: Top 57%
Cardiac Fibrosis and Remodeling
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Comparative cardioprotective effects of Kuanxiong Aerosol and its individual components in a rat model of acute myocardial infarction — Xiaokang Peng, Yuan-hang Zheng, et al. · Pharmaceutical Biology (2026) | TGRS Research Map | TGRS