Clinical, social, molecular, and genetic predictors of cognitive resilience in long-living adults without dementia
Our findings corroborated established risk factors for cardiovascular diseases and identified population-specific patterns, with APOE ε4 showing no significant association. Both protein-coding regions and non-coding elements were implicated in CI, suggesting that it is underlain by complex regulatory mechanisms.
Authors
- IRINA STRAZHESKO
- E. D. Spektor (ORCID: https://orcid.org/0000-0003-0714-9476)
- S. M. Yudin (ORCID: https://orcid.org/0000-0002-7942-8004)
- Anton А. Keskinov (ORCID: https://orcid.org/0000-0001-7378-983X)
- A. M. Rumyantseva (ORCID: https://orcid.org/0009-0006-4830-8057)
- Д. А. Каштанова (ORCID: https://orcid.org/0000-0001-8977-4384)
- V. S. Yudin (ORCID: https://orcid.org/0000-0002-9199-6258)
- M. T. Ivanov
- А. А. Мамчур (ORCID: https://orcid.org/0000-0002-6025-7663)
- Lorena Matkava (ORCID: https://orcid.org/0009-0004-2039-9618)
- O. N. Tkacheva
- Valentin Makarov
- Veronika Daniel
- Mariia Bruttan
- Sergey Igorevich Mitrofanov
- Liliya Artemieva
- Veronika Skvortsova
Institutions
- Pirogov Russian National Research Medical University (RU)
- Federal Agency for Health and Social Development (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Frontiers in Dementia
- Published
- 2026-02-16
- DOI
- https://doi.org/10.3389/frdem.2025.1699695
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00