Sex Differences in P-Tau217, Tau Aggregation, and Cognitive Decline
These findings add to growing evidence that women have a differential tau response to Aβ that may emerge at the point of p-tau secretion. These findings have implications for the therapeutics and diagnostics of preclinical Alzheimer disease.
Authors
- Andrée‐Ann Baril (ORCID: https://orcid.org/0000-0002-9710-5348)
- Cheryl Brown
- Oliver Langford (ORCID: https://orcid.org/0009-0006-8951-1326)
- S. R. Arnold (ORCID: https://orcid.org/0000-0002-4881-5685)
- Pia Kivisäkk Webb
- Alan C. Evans (ORCID: https://orcid.org/0000-0003-3841-6098)
- Judes Poirier
- Cecily Jenkins
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- R. Green
- John C.S. Breitner (ORCID: https://orcid.org/0000-0003-4229-4687)
- Alison Belsha
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Marianne Manire
- Bellec Pierre
- Mike Rafii
- Emma G. Thibault (ORCID: https://orcid.org/0000-0002-7873-742X)
- Emilie T. Reas (ORCID: https://orcid.org/0000-0002-4110-5154)
- Véronique D. Bohbot
- Murali Doraiswamy
- Hannah M Klinger
- Renarda Jones
- Madison Cuppels
- Simon Ducharme
- Sylvain Baillet
- REMA RAMAN (ORCID: https://orcid.org/0000-0002-4096-6390)
- Nathan R Spreng
- R. Yaari (ORCID: https://orcid.org/0000-0002-3149-8361)
- Danilo Bzdok
- Marybeth Howlett
- Taylor W. Schmitz
- Colin Birkenbihl
- Natasha Rajah
- Paul Aisen
- Orest Hurko
- James B. Brewer
- Clifford Jack Jr.
- Jane A. Brown
- Rachelle Doody
- John Seibyl
- Rebecca Langhough
- Mahsa Dadar
- Annie Li
- Thomas Obisesan
- Vasavan Nair
- Michael C. Donohue
- Isabella Velon
- Christine Tardif
- D. Louis Collins
- Lisa-Marie Münter
- Jason Karlawish
- Aaron Schultz
- JoAnn E. Manson
- Christian Bocti
- Rick Hoge
- Mark Mintun
- Karen Holdridge
- Valentin Ourry
- Hyun-Sik Yang
- Jeffrey Kaye
- Sylvia Villeneuve
- Maiya Geddes
- Daniel Auld
- Maria Arampatizdou
- Robert A. Rissman
- Reisa Sperling
- Paula Cohen
- Gerhard Multhaup
- Pierre Etienne
- Jean-Paul Soucy
- Mallar Chakravarty
- Etienne Vachon-Presseau
- Michelle Farrell
- Robert Laforce
- Jennifer Salazar
- Vedeline Torreon
- Paul Maruff
- Michael Properzi
- Mabel Seto
- Doug Scharre
- Jens Pruessner
- Michael W Weiner
- Gustavo Jimenez-Maggiora
- Serge Gauthier
- Diana Townsend
- Sanra E Black
- Sterling C. Johnson
- Keith Johnson
- Maxime Descoteaux
- John R. Sims
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Autism Research Institute (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- The University of Melbourne (AU)
- Massachusetts General Hospital (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- McGill University (CA)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1001/jamaneurol.2025.5670
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00