The kynurenine pathway in relation to depression and anhedonia symptom severity among women with HIV
This study extends understanding of the role of the KP in depression and anhedonia to WWH and suggests neuroactive metabolites as a possible underlying mechanism. The KP may affect reward neuro-circuitry through increased QA neurotoxicity and decreased KA neuroprotection.
Authors
- Helen J. Burgess (ORCID: https://orcid.org/0000-0003-3816-8194)
- Caitlin Hills (ORCID: https://orcid.org/0000-0001-5024-5231)
- Marina B. Klein (ORCID: https://orcid.org/0000-0002-3063-8430)
- Francisco Cardozo (ORCID: https://orcid.org/0000-0002-1925-4954)
- Aaron B. Chance (ORCID: https://orcid.org/0000-0003-0980-1253)
- QIBIN QI
- Kathleen M. Weber (ORCID: https://orcid.org/0009-0006-8988-6929)
- Wenzhu Mowrey (ORCID: https://orcid.org/0000-0002-7407-7014)
- Vilma Gabbay
- Zoe Baker
- Audrey L. French
- Anjali Sharma
- Deborah R. Gustafson
- Joan W. Berman
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
- Albert Einstein College of Medicine (US)
- Johns Hopkins University (US)
- University of Miami (US)
- SUNY Downstate Health Sciences University (US)
- University of Michigan (US)
- University of Illinois Chicago (US)
- Hektoen Institute (US)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1016/j.bbih.2026.101199
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 27.61