Chikungunya virus‐induced persistent allodynia is accompanied by joint microenvironmental changes and involves cartilage degradation and TRPA1 activation
Insights into CHIKV-associated pain have been made giving a guide to targeted analgesic strategies. CHIKV or its RNA injection triggers bilateral secondary mechanical allodynia, accompanied by knee joint damage and a TRPA1-dependent mechanism. Indicating TRPA1 blockers have the potential to be repurposed or further investigated for the clinical management of CHIKV-associated chronic pain.
Authors
- Matilde Marini (ORCID: https://orcid.org/0000-0002-2199-2905)
- Martina Chieca (ORCID: https://orcid.org/0000-0002-0247-9938)
- Lucas Zanon Mascarin
- João de Sousa Valente (ORCID: https://orcid.org/0000-0003-1888-6324)
- João Β. Calixto (ORCID: https://orcid.org/0000-0003-4041-7153)
- Catielen Paula Pavi (ORCID: https://orcid.org/0000-0003-2506-3772)
- Laryssa Regis Bueno (ORCID: https://orcid.org/0000-0002-3583-3200)
- Beatriz Pereira Savi (ORCID: https://orcid.org/0000-0002-7948-6212)
- Daniele Maria‐Ferreira (ORCID: https://orcid.org/0000-0001-7992-510X)
- Ayda Henriques Schneider
- Adara A. Santos (ORCID: https://orcid.org/0000-0003-2309-4890)
- Seigo Nagashima (ORCID: https://orcid.org/0000-0003-0069-3823)
- Susan D. Brain (ORCID: https://orcid.org/0000-0002-9684-8342)
- Gislaine Fongaro (ORCID: https://orcid.org/0000-0001-5596-3320)
- Samara Damasceno (ORCID: https://orcid.org/0000-0002-0215-4420)
- Silva Júnior
- Fernanda Capitânio Goldoni (ORCID: https://orcid.org/0000-0002-0950-8228)
- Heloisa Immianovsky Eisendecker (ORCID: https://orcid.org/0009-0009-6446-0384)
- Andressa Caroline dos Santos Maia (ORCID: https://orcid.org/0000-0003-4010-8473)
- Nágila C. F. de Sousa
- Elizabeth S. Fernandes
- Liziane C. M. da Silva
- Thiago M. Cunha
- Izabella T. Silva
- Nara L. M. Quintao
- Lúcia de Noronha
- Soraia K. P. Costa
- João F. S. Rodrigues
- Maria R. Q. Bomfim
- Romina Nassini
Institutions
- Universidade de Ribeirão Preto (BR)
- Pontifícia Universidade Católica do Paraná (BR)
- Universidade de São Paulo (BR)
- King's College London (GB)
- Aarhus University (DK)
- London South Bank University (GB)
- Universidade Federal de Santa Catarina (BR)
- Unidade Integrada de Farmacologia e Gastroenterologia (BR)
- Instituto de Tecnologia do Paraná (BR)
- King's College School (GB)
- Associação Saúde da Família (BR)
- Universidade do Vale do Itajaí (BR)
- Farmacore (Brazil) (BR)
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (BR)
- University of Florence (IT)
- Universidade Luterana do Brasil (BR)
- Universidade Federal do Paraná (BR)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-02-16
- DOI
- https://doi.org/10.1111/bph.70362
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00