Mapping the knowledge landscape of silver-modified TiO₂ nanotube arrays for orthopedic applications

Abstract Silver-modified titanium dioxide (TiO₂) nanotube arrays (TNTs) have emerged as multifunctional implant coatings capable of providing antibacterial protection while supporting osteogenic activity. Their tunable nanotubular morphology, high surface area, and ability to incorporate Ag nanoparticles or ions enable controlled antimicrobial action without compromising cytocompatibility. To map the evolution of this rapidly growing research domain, a bibliometric analysis was conducted on publications retrieved from the Dimensions database (2006–2025). A total of more than 1600 documents were analyzed using VOSviewer and MS Excel to evaluate global publication trends, influential authors, institutions, and collaboration networks. Results indicate a marked rise in research output over the past decade, with China, the United States, and Germany emerging as leading contributors in both productivity and impact. Seminal works primarily focus on Ag-release kinetics, antibacterial mechanisms, and biological responses at the implant interface. This analysis highlights key research clusters, emerging themes, and persistent knowledge gaps, providing a consolidated perspective for advancing next-generation infection-resistant implant surfaces. The findings support strategic planning and interdisciplinary collaboration toward scalable, clinically relevant Ag–TiO₂ nanotube technologies. Overall, this work provides engineering-oriented insights into how Ag–TiO₂ nanotube architectures, ion-release control, and multifunctional surface modification strategies are evolving toward scalable, clinically relevant antimicrobial coatings. These findings support future process optimization and materials design efforts within the chemical engineering aspects of biomedical surface engineering.