Conductive Hearing Loss Pathologies are Associated With Dementia in the All of Us Research Program

Cholesteatoma and TM perforation were associated with dementia in the All of Us Research Program. Treatment attenuates these relationships. Given the general implausibility for dementia to cause these CHL pathologies, reverse causation-that dementia causes hearing loss-is an unlikely explanation for the association. This study adds to the evidence that cognition is impacted by sensory deprivation but extends to correctable conductive causes.

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Publication Details

Journal
Otolaryngology
Published
2026-02-16
DOI
https://doi.org/10.1002/ohn.70152
Primary Topic
Hearing Loss and Rehabilitation
Type
article
Field-Weighted Citation Impact
0.00
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article

Conductive Hearing Loss Pathologies are Associated With Dementia in the All of Us Research Program

Michael W. Denham, Lauren H. Tucker, Richard Klaus Gurgel, Justin S. Golub et al.
Otolaryngology
Hearing Loss and Rehabilitation
article

Conductive Hearing Loss Pathologies are Associated With Dementia in the All of Us Research Program

Michael W. Denham, Lauren H. Tucker, Richard Klaus Gurgel, Justin S. Golub, Hannah N. W. Weinstein, S. Dillon Powell
article en

Abstract

Cholesteatoma and TM perforation were associated with dementia in the All of Us Research Program. Treatment attenuates these relationships. Given the general implausibility for dementia to cause these CHL pathologies, reverse causation-that dementia causes hearing loss-is an unlikely explanation for the association. This study adds to the evidence that cognition is impacted by sensory deprivation but extends to correctable conductive causes.

Otolaryngology
University of Utah (US), Columbia University Irving Medical Center (US), Columbia University (US)
Good health and well-being
Openalex Percentile: Top 56%
Hearing Loss and Rehabilitation
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Conductive Hearing Loss Pathologies are Associated With Dementia in the All of Us Research Program — Michael W. Denham, Lauren H. Tucker, et al. · Otolaryngology (2026) | TGRS Research Map | TGRS