Взаємозв’язок між патологією гепатобіліарної системи та станом органів порожнини рота

Aim: to determine the relationship between hepatobiliary system (HBS) pathology and oral health status based on a synthesis of professional literature. Materials and methods. A bibliosemantic analysis was performed on research results from Ukrainian and international professional literature indexed in PubMed, Scopus, Web of Science, and Google Scholar. The search utilized keywords: hepatobiliary system, liver diseases, biliary tract diseases, dental caries, periodontitis, and oral mucosal diseases. Results. The study indicates that pathological changes in the hepatobiliary complex disrupt numerous vital systemic processes. Existing research has explored the development of hepatorenal, hepatoencephalic, hepatopulmonary, dermatological, and cardiovascular syndromes associated with HBS pathology. The authors have identified a significant influence of hepatobiliary diseases on the development of oral conditions, specifically affecting the periodontium, oral mucosa, salivary glands, and dental hard tissues. Furthermore, periodontitis is increasingly recognized as a risk factor that may contribute to the progression of hepatobiliary pathology. Evidence confirms a bidirectional correlation between HBS disorders and oral tissue health. Conclusions. Impairment of hepatic metabolic functions, including protein synthesis, accumulation, and distribution, as well as hormone and vitamin regulation and the activation of pro-inflammatory processes, negatively impacts various organ systems. It has been established that microbiome alterations observed in periodontitis play a significant role in the pathogenesis of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Hepatobiliary pathology impairs the regeneration of both connective tissue and bone structures within the oral cavity. Clinical and experimental data also confirm that viral hepatitis is frequently accompanied by pathological changes in the salivary glands.