Epicardial fat remodeling in end-stage heart failure with reduced ejection fraction
LV EAT in HFrEF contains smaller adipocytes and has higher density in CT images, exhibits pronounced cell size/density gradient and is more heterogeneous than in non-HF subjects. Thus LV EAT undergoes complex remodeling in HFrEF. Further studies are needed to elucidate the mechanisms driving this remodeling, determine whether it can be therapeutically targeted, and assess which parameters may have prognostic value in patients with HFrEF.
Authors
- Przemysław Leszek (ORCID: https://orcid.org/0000-0003-4529-2687)
- Michał Ma̧czewski (ORCID: https://orcid.org/0000-0002-3157-4141)
- Zuzanna Wojdyńska
- Mateusz Smoliński (ORCID: https://orcid.org/0000-0002-3890-5943)
- Ilona M. Michałowska (ORCID: https://orcid.org/0000-0002-6237-4206)
- Marcel Nowakowski (ORCID: https://orcid.org/0000-0001-8928-457X)
- Aleksandra Paterek
- Łukasz Nogajski
- Maciej Mazuruk
- Marta Kacperska
- Mikołaj Kurpias
- Oliwia Łuniewska
- Hanna Czerwińska
- Filip Pilzak
- Aleksandra Świstak
- Marta Załęska-Kocięcka
- Igor Gronek
- Maciej Mączewski
Institutions
- Medical University of Warsaw (PL)
- Postgraduate School of Molecular Medicine (PL)
- Institute of Cardiology (PL)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-02-15
- DOI
- https://doi.org/10.1186/s12933-026-03106-2
- Citations
- 1
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 30.07