Systematic Druggable Genome-Wide Mendelian Randomization Identifies Genetically Supported Therapeutic Targets for Coronary Artery Disease
We identified circulating ERP29, MCL1, TNXB, DAGLB, FES, TRPM4, MAPK3, and TNF as promising, genetically supported druggable targets for CAD treatment. Notably, MAPK3 and TNF demonstrated strong protein-level interactions and close associations with cardiometabolic disorders.
Authors
- Wenfu Tao
- Mingli Li
- Zengnan Mo
- Boteng Yan
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- First People's Hospital of Nanning (CN)
- Center for Genomic Science (IT)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-02-12
- DOI
- https://doi.org/10.2174/0109298673426660251215100614
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00