<i>Alms1</i> <scp>KO</scp> Rat: A New Model of Cardiometabolic Syndrome With Spontaneous Hypertension
Collectively, these findings establish the Alms1 KO rat as a robust preclinical model of metabolic syndrome. This model closely mimics human disease and provides a powerful tool for studying the mechanisms of metabolic and cardiovascular dysfunction as well as for testing potential therapeutic interventions.
Authors
- Sumit R. Monu (ORCID: https://orcid.org/0000-0003-1906-3063)
- Ankita B. Jaykumar (ORCID: https://orcid.org/0000-0002-9396-5850)
- Mariela Méndez (ORCID: https://orcid.org/0000-0002-2537-7272)
- Pablo A. Ortiz (ORCID: https://orcid.org/0000-0002-7512-7255)
- Jiang Xu (ORCID: https://orcid.org/0009-0001-3822-0397)
- Xiaoping Yang (ORCID: https://orcid.org/0000-0003-1263-2710)
- Nour‐Eddine Rhaleb
Institutions
- Wayne State University (US)
- Henry Ford Hospital (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-02-15
- DOI
- https://doi.org/10.1111/apha.70174
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00