SLC1A5-mediated kynurenine metabolism drives AHR-FANCD2 axis to remodel chromatin and induce T cell exhaustion in lung adenocarcinoma

This study suggests that SLC1A5 is upregulated in TEX, which modulates kynurenine metabolism and induces T cell exhaustion through the AHR-FANCD2 axis-mediated chromatin remodeling.

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Publication Details

Journal
Cell Communication and Signaling
Published
2026-02-16
DOI
https://doi.org/10.1186/s12964-026-02732-3
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

SLC1A5-mediated kynurenine metabolism drives AHR-FANCD2 axis to remodel chromatin and induce T cell exhaustion in lung adenocarcinoma

Haoji Wang, Xinnan Xu, Li Xu, Yanxi Yao et al.
Cell Communication and Signaling
Tryptophan and brain disorders
article

SLC1A5-mediated kynurenine metabolism drives AHR-FANCD2 axis to remodel chromatin and induce T cell exhaustion in lung adenocarcinoma

Haoji Wang, Xinnan Xu, Li Xu, Yanxi Yao, Hongdou Ding, Yifei Zhu
article en

Abstract

This study suggests that SLC1A5 is upregulated in TEX, which modulates kynurenine metabolism and induces T cell exhaustion through the AHR-FANCD2 axis-mediated chromatin remodeling.

Cell Communication and SignalingVol. 24(1)
Shanghai Medical College of Fudan University (CN), Shanghai Jiao Tong University (CN), Renji Hospital (CN), Fudan University Shanghai Cancer Center (CN), Shanghai Pulmonary Hospital (CN)
Openalex Percentile: Top 58%
Tryptophan and brain disorders
DOIOpen Access PDFOpenAlex
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SLC1A5-mediated kynurenine metabolism drives AHR-FANCD2 axis to remodel chromatin and induce T cell exhaustion in lung adenocarcinoma — Haoji Wang, Xinnan Xu, et al. · Cell Communication and Signaling (2026) | TGRS Research Map | TGRS