Highly Efficient One‐Pot Synthesis of New Theino[2,3‐ <i>b</i> ] Pyridine and Pyrimido[1,2‐ <i>a</i> ]Pyrimidine Scaffolds as Potential Antimicrobial Activity

ABSTRACT Thienopyridine and nicotinonitrile, a new class of desired compounds with higher yields in the current investigations, were produced by the one‐step method of 2‐thiooxopyridines and halogen‐based compounds in ethanol using catalytic amounts of EtONa under continuous stirring at 90°C for 2 h. Moreover, aldehyde, other active methylene reagents, and 2‐aminopyrimidine with catalytic amounts of AcONH 4 are used in a one‐pot procedure to obtain primidopyrimidines. This approach has achieved good to excellent yields for the desired compounds 6–9 and 12 by optimization of the reaction conditions. Medium response, rapid speed, and ease of application are the main features of this technique. Additionally, each compound has been proven to be resistant to dangerous microbes. The primopyrimidine derivative 12a has the best antimicrobial activity when compared to standard drugs, having MIC measurements that varied from 6.24 to 58.74 µM.