LncRNA HOXC-AS3 prevents chondrocyte senescence and osteoarthritis progression through miR-615-3p sponging and RRBP1 interaction

This study establishes lncRNA HOXC-AS3 as a key regulator of chondrocyte homeostasis that mitigates OA progression via dual mechanisms-miR-615-3p sponging and RRBP1 interaction-both of which maintain CIT expression. These findings advance the understanding of the molecular networks underlying OA pathogenesis and underscore HOXC-AS3 and its downstream signaling axis as promising therapeutic targets for OA intervention.

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Publication Details

Journal
Cell & Bioscience
Published
2026-02-15
DOI
https://doi.org/10.1186/s13578-026-01541-y
Primary Topic
Osteoarthritis Treatment and Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

LncRNA HOXC-AS3 prevents chondrocyte senescence and osteoarthritis progression through miR-615-3p sponging and RRBP1 interaction

Changyan Ma, Zhan Dong, Lie Chen, Chan Wang et al.
Cell & Bioscience
Osteoarthritis Treatment and Mechanisms
article

LncRNA HOXC-AS3 prevents chondrocyte senescence and osteoarthritis progression through miR-615-3p sponging and RRBP1 interaction

Changyan Ma, Zhan Dong, Lie Chen, Chan Wang, Dengshun Miao, Jun Zhou
article en

Abstract

This study establishes lncRNA HOXC-AS3 as a key regulator of chondrocyte homeostasis that mitigates OA progression via dual mechanisms-miR-615-3p sponging and RRBP1 interaction-both of which maintain CIT expression. These findings advance the understanding of the molecular networks underlying OA pathogenesis and underscore HOXC-AS3 and its downstream signaling axis as promising therapeutic targets for OA intervention.

Cell & BioscienceVol. 16(1)
Nanjing Children's Hospital (CN), Plastic Surgery Hospital (CN), Suizhou Central Hospital (CN), Jiangsu Vocational College of Medicine (CN), Second Affiliated Hospital of Nanjing Medical University (CN), Nanjing Medical University (CN)
Openalex Percentile: Top 56%
Osteoarthritis Treatment and Mechanisms
DOIOpen Access PDFOpenAlex
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