Inside Back Cover: Programmable Antigen‐Specific Immunity via Self‐Adjuvanting Nanovaccines Co‐Delivering Immune Modulators (Angew. Chem. Int. Ed. 11/2026)
Self-adjuvanting vaccines—covalent conjugates of antigens and adjuvants—elicit robust antigen-specific immunity. In the Research Article (e20474), Yoshiyuki Manabe, Yoshie Kametani, Koichi Fukase, and co-workers formulated self-adjuvanting vaccines into cationic lipid nanoparticles (< 100 nm) incorporating supplemental adjuvants. These nanovaccines exhibited potent immunogenicity in humanized mouse models, underscoring their translational potential for cancer immunotherapy.
Authors
- Manabu Tokeshi (ORCID: https://orcid.org/0000-0002-4412-2144)
- Kazuya Kabayama (ORCID: https://orcid.org/0000-0002-7583-5454)
- Yoshie Kametani (ORCID: https://orcid.org/0000-0002-7417-1836)
- Shino Ohshima (ORCID: https://orcid.org/0000-0003-0825-6572)
- Yoshiyuki Manabe (ORCID: https://orcid.org/0000-0002-5515-3923)
- Hiroshi Inaba (ORCID: https://orcid.org/0000-0002-7658-7827)
- Masatoshi Maeki (ORCID: https://orcid.org/0000-0001-7500-4231)
- Kazunori Matsuura (ORCID: https://orcid.org/0000-0001-5472-7860)
- Keita Ito
- Koichi Fukase
Institutions
- Hokkaido University of Science (JP)
- Tokai University (JP)
- Hokkaido University (JP)
- Toneyama National Hospital (JP)
- Tottori University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-02-15
- DOI
- https://doi.org/10.1002/anie.2026-m0402124700
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00