Multi-gene biomarkers reveal spatial organization and subpopulation-specific damage response in intrahepatic biliary epithelial cells
Novel metagene biomarkers of BEC subpopulations facilitated spatial localization of BECs in situ, identified subpopulation specific injury responses, and confirmed that BEC heterogeneity is preserved in vitro. The presence of locally homogenous BEC neighborhoods in vitro suggests some degree of BEC organization may be epithelial-autonomous.
Authors
- Hannah R. Hrncir (ORCID: https://orcid.org/0000-0002-3686-2492)
- Sergei Bombin (ORCID: https://orcid.org/0000-0002-8333-932X)
- Fransky Hantelys (ORCID: https://orcid.org/0000-0003-3504-2916)
- Adam D. Gracz
- Kendall G Kanakanui (ORCID: https://orcid.org/0000-0002-1523-3566)
Institutions
- University of North Carolina at Chapel Hill (US)
- Emory University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-02-15
- DOI
- https://doi.org/10.64898/2026.02.12.705355
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00