Time-robust myocardial [68Ga]Ga-FAPI PET biomarker reflects aortic stenosis severity and predicts post-TAVI outcomes

Myocardial [<sup>68</sup>Ga]Ga-FAPI TBR may provide a time-robust index of active fibroblast signaling that relates to myocardial hemodynamic stress and stratifies one-year clinical response after TAVI. A single 60-minute acquisition with TBR quantification may be sufficient for myocardial [<sup>68</sup>Ga]Ga-FAPI assessment. These hypothesis-generating findings require validation in larger, multicenter cohorts.

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Publication Details

Journal
European Journal of Nuclear Medicine and Molecular Imaging
Published
2026-02-16
DOI
https://doi.org/10.1007/s00259-026-07815-4
Primary Topic
Peptidase Inhibition and Analysis
Type
article
Field-Weighted Citation Impact
0.00

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article

Time-robust myocardial [68Ga]Ga-FAPI PET biomarker reflects aortic stenosis severity and predicts post-TAVI outcomes

Kevin Hamzaraj, Aleksa Lazarević, Attila Kiss, Qianling Ye et al.
European Journal of Nuclear Medicine and Molecular Imaging
Peptidase Inhibition and Analysis
article

Time-robust myocardial [68Ga]Ga-FAPI PET biomarker reflects aortic stenosis severity and predicts post-TAVI outcomes

Kevin Hamzaraj, Aleksa Lazarević, Attila Kiss, Qianling Ye, Christian Nitsche, Xiang Li, Patrick Binder, Bruno K Podesser, Song Xue, Marcus Hacker
article en

Abstract

Myocardial [<sup>68</sup>Ga]Ga-FAPI TBR may provide a time-robust index of active fibroblast signaling that relates to myocardial hemodynamic stress and stratifies one-year clinical response after TAVI. A single 60-minute acquisition with TBR quantification may be sufficient for myocardial [<sup>68</sup>Ga]Ga-FAPI assessment. These hypothesis-generating findings require validation in larger, multicenter cohorts.

European Journal of Nuclear Medicine and Molecular Imaging
Capital Medical University (CN), Vienna General Hospital (AT), Ludwig Boltzmann Institute for Cardiovascular Research (AT), Ludwig Boltzmann Institute for Cancer Research (AT), Medical University of Vienna (AT)
Universität Wien, Medizinische Universität Wien
Good health and well-being
Openalex Percentile: Top 55%
Peptidase Inhibition and Analysis
DOIOpen Access PDFOpenAlex
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Time-robust myocardial [68Ga]Ga-FAPI PET biomarker reflects aortic stenosis severity and predicts post-TAVI outcomes — Kevin Hamzaraj, Aleksa Lazarević, et al. · European Journal of Nuclear Medicine and Molecular Imaging (2026) | TGRS Research Map | TGRS