Digital biology and the ethics of codified health systems

Digital biology is transforming global health by rendering biological systems programmable through data-intensive models, algorithmic decision-making, and transnational data infrastructures, creating new governance challenges around equity, accountability, and power. This commentary advances the central contribution that ethics in digital biology must be understood and designed as governance infrastructure, embedded within data architectures, system design, and institutional arrangements, rather than treated as downstream compliance or ethical guidance. This reframing matters for global health institutions, particularly the World Health Organisation (WHO), as effective oversight of codified health systems will require new roles in setting validation standards, lifecycle accountability mechanisms, and interoperable governance frameworks capable of operating across jurisdictions and resource-constrained contexts.