Network Pharmacology and Experimental Approaches Reveal theEffects of Scutellaria barbata Flavonoids Against Alzheimer's DiseaseviaCREB Phosphorylation in Rats

Network pharmacology analysis and animal experiments confirmed that SBFs promote neurogenesis and ameliorate learning and memory impairment in AD model rats, primarily by facilitating CREB phosphorylation, similar to Rolipram. This study indicates that SBFs may be a promising therapeutic candidate for the treatment of AD.

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Publication Details

Journal
Current Medicinal Chemistry
Published
2026-02-02
DOI
https://doi.org/10.2174/0109298673417632251125054314
Primary Topic
Flavonoids in Medical Research
Type
article
Field-Weighted Citation Impact
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article

Network Pharmacology and Experimental Approaches Reveal theEffects of Scutellaria barbata Flavonoids Against Alzheimer's DiseaseviaCREB Phosphorylation in Rats

Shang Yazhen, Li Caixia, HUO Jing, Liu Yuling et al.
Current Medicinal Chemistry
Flavonoids in Medical Research
article

Network Pharmacology and Experimental Approaches Reveal theEffects of Scutellaria barbata Flavonoids Against Alzheimer's DiseaseviaCREB Phosphorylation in Rats

Shang Yazhen, Li Caixia, HUO Jing, Liu Yuling, Liu Xinyang, Ma Shuai, He Ke, Gao Yang, Cheng Jianjun
article en

Abstract

Network pharmacology analysis and animal experiments confirmed that SBFs promote neurogenesis and ameliorate learning and memory impairment in AD model rats, primarily by facilitating CREB phosphorylation, similar to Rolipram. This study indicates that SBFs may be a promising therapeutic candidate for the treatment of AD.

Current Medicinal ChemistryVol. 33
Hebei Medical University (CN), Chengde Medical University (CN), Fourth Hospital of Hebei Medical University (CN), Chengde Medical University (CN), Beijing Xuanwu Traditional Chinese Medicine Hospital (CN), First Hospital of Shijiazhuang (CN)
Openalex Percentile: Top 54%
Flavonoids in Medical Research
DOISourceOpenAlex
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