Formulation and Evaluation of Monk Fruit Extract-Based Zero-Calorie Electrolyte Replenisher Powder: A Novel Functional Formulation

The present study aims to develop and evaluate a natural, zero-calorie electrolyte replenisher formulated using monk fruit extract (Siraitia grosvenorii) as a non-glycemic sweetener. Considering the increasing prevalence of diabetes, obesity, and excessive sugar consumption, this formulation provides a healthier alternative to conventional sugar-based oral rehydration products. A WHO ORS–derived electrolyte composition containing sodium chloride, potassium chloride, trisodium citrate, citric acid, and monk fruit extract was prepared by dry blending and packed in moisture-proof sachets. Physicochemical evaluation demonstrated favorable organoleptic properties, rapid solubility (28 ± 2 s), slightly acidic pH (6.5 ± 0.1), and low moisture content (2.1%), indicating good initial quality. Accelerated stability testing at 40°C/75% RH for 28 days showed a gradual increase in moisture content (up to 3.5%) and mild caking, while pH remained stable (6.4–6.5), confirming the absence of chemical degradation. The results suggest that the formulation is primarily affected by hygroscopicity and requires strong moisture-proof packaging for extended shelf life. Overall, the study demonstrates that monk fruit–sweetened electrolyte powder is a viable, stable, and clean-label alternative suitable for diabetics, ketogenic users, athletes, and general consumers seeking natural, zero-calorie hydration solutions. Further sensory and clinical studies are recommended to optimize taste and validate rehydration efficacy. Keywords: Monk fruit; Mogrosides; Zero-calorie natural sweetener; Electrolyte replenisher; Hydration therapy; Diabetes-friendly formulation

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Publication Details

Journal
Journal of Drug Delivery and Therapeutics
Published
2026-02-15
DOI
https://doi.org/10.22270/jddt.v16i2.7549
Primary Topic
Biochemical Analysis and Sensing Techniques
Type
article
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article

Formulation and Evaluation of Monk Fruit Extract-Based Zero-Calorie Electrolyte Replenisher Powder: A Novel Functional Formulation

Ravina Khandekar, Unnati Suresh Patil, Darshan Shejwal, Monali Gangurde et al.
Journal of Drug Delivery and Therapeutics
Biochemical Analysis and Sensing Techniques
article

Formulation and Evaluation of Monk Fruit Extract-Based Zero-Calorie Electrolyte Replenisher Powder: A Novel Functional Formulation

Ravina Khandekar, Unnati Suresh Patil, Darshan Shejwal, Monali Gangurde, Snehal Ukhade
article en

Abstract

The present study aims to develop and evaluate a natural, zero-calorie electrolyte replenisher formulated using monk fruit extract (Siraitia grosvenorii) as a non-glycemic sweetener. Considering the increasing prevalence of diabetes, obesity, and excessive sugar consumption, this formulation provides a healthier alternative to conventional sugar-based oral rehydration products. A WHO ORS–derived electrolyte composition containing sodium chloride, potassium chloride, trisodium citrate, citric acid, and monk fruit extract was prepared by dry blending and packed in moisture-proof sachets. Physicochemical evaluation demonstrated favorable organoleptic properties, rapid solubility (28 ± 2 s), slightly acidic pH (6.5 ± 0.1), and low moisture content (2.1%), indicating good initial quality. Accelerated stability testing at 40°C/75% RH for 28 days showed a gradual increase in moisture content (up to 3.5%) and mild caking, while pH remained stable (6.4–6.5), confirming the absence of chemical degradation. The results suggest that the formulation is primarily affected by hygroscopicity and requires strong moisture-proof packaging for extended shelf life. Overall, the study demonstrates that monk fruit–sweetened electrolyte powder is a viable, stable, and clean-label alternative suitable for diabetics, ketogenic users, athletes, and general consumers seeking natural, zero-calorie hydration solutions. Further sensory and clinical studies are recommended to optimize taste and validate rehydration efficacy. Keywords: Monk fruit; Mogrosides; Zero-calorie natural sweetener; Electrolyte replenisher; Hydration therapy; Diabetes-friendly formulation

Journal of Drug Delivery and TherapeuticsVol. 16(2)
Sandip Foundation (IN)
Openalex Percentile: Top 53%
Biochemical Analysis and Sensing Techniques
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