Metabolic Rewiring at the Pyruvate Node Drives Severe Pneumonia and T-Cell Suppression in Serotype 3 <i>Streptococcus pneumoniae</i> Infection

The SpxB-dependent pathway orchestrates ST3 virulence by enabling metabolic adaptation and driving bleb-mediated epithelial invasion and immune evasion in the lung. These bacterium-laden blebs represent a novel hallmark mechanism in pneumococcal pathogenesis, offering new insights and potential therapeutic targets.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-02-15
DOI
https://doi.org/10.64898/2026.02.13.705843
Primary Topic
Pneumonia and Respiratory Infections
Type
article
Field-Weighted Citation Impact
0.00
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article

Metabolic Rewiring at the Pyruvate Node Drives Severe Pneumonia and T-Cell Suppression in Serotype 3 Streptococcus pneumoniae Infection

Jorge Eugenio Vidal, Ana G. Jop Vidal
bioRxiv (Cold Spring Harbor Laboratory)
Pneumonia and Respiratory Infections
article

Metabolic Rewiring at the Pyruvate Node Drives Severe Pneumonia and T-Cell Suppression in Serotype 3 Streptococcus pneumoniae Infection

Jorge Eugenio Vidal, Ana G. Jop Vidal
article en

Abstract

The SpxB-dependent pathway orchestrates ST3 virulence by enabling metabolic adaptation and driving bleb-mediated epithelial invasion and immune evasion in the lung. These bacterium-laden blebs represent a novel hallmark mechanism in pneumococcal pathogenesis, offering new insights and potential therapeutic targets.

bioRxiv (Cold Spring Harbor Laboratory)
University of Mississippi Medical Center (US)
Good health and well-being
Openalex Percentile: Top 54%
Pneumonia and Respiratory Infections
DOIOpen Access PDFOpenAlex
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Metabolic Rewiring at the Pyruvate Node Drives Severe Pneumonia and T-Cell Suppression in Serotype 3 <i>Streptococcus pneumoniae</i> Infection — Jorge Eugenio Vidal, Ana G. Jop Vidal · bioRxiv (Cold Spring Harbor Laboratory) (2026) | TGRS Research Map | TGRS