Recurrent Second‐Trimester Euploid Pregnancy Loss Associated With Maternal–Paternal HLA Compatibility: Review Based on a Case Report of Immune‐Mediated Failure
Excessive maternal-paternal HLA compatibility may contribute to recurrent euploid pregnancy loss through disruption of maternal-fetal immune tolerance. This case-based review underscores the need for individualized immunologic assessment and further research into targeted therapies for alloimmune-mediated reproductive failure.
Authors
- Eva Choong (ORCID: https://orcid.org/0000-0001-6776-4978)
- David H. Barad (ORCID: https://orcid.org/0000-0002-7980-2369)
- Norbert Gleicher
- Lara Guijarro‐Baude
- Sonia Gayete‐Lafuente
Institutions
- Hospital Universitari de Vic (ES)
- Foundation for Reproductive Medicine (US)
- Center for Human Reproduction (US)
- Medical University of Vienna (AT)
- Rockefeller University (US)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/aji.70217
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00