Network Pharmacology and Molecular Docking Analyses of Jiao-Tai-Wan Indicate that Adenosine and its Receptors are Potential Targets forTreating Insomnia

We screened potential targets for JTW in the treatment of insomnia using network pharmacology, which included adenosine receptors. Subsequently, we verified the effects of JTW on the adenosine signaling pathway through molecular docking and animal experiments and clarified the regulatory effect of JTW on the adenosine signaling pathway in animal models of insomnia Conclusion: Jiao-Tai-Wan (JTW) ameliorates insomnia through a multi-target mechanism that modulates adenosinergic signaling by reducing elevated adenosine levels and upregulating A1R/A2AR receptor expression.