Epigenetic age acceleration in young adults with congenital heart disease
Young ACHD patients who undergo multiple childhood surgeries for Fontan palliation were associated with accelerated aging. These changes could reflect the long-term effects of underlying CHD condition, early-life physiological stress and other factors, potentially involving inflammatory pathways. Further research is needed to identify and validate the key factors contributing to EAA in this population and to clarify the role of chronic stress and physiological alterations over time.
Authors
- Joanne Whitehead (ORCID: https://orcid.org/0000-0002-9602-2081)
- J Macisaac
- Paul A. Checchia (ORCID: https://orcid.org/0000-0003-0364-2052)
- M Kobor
- Parag Jain (ORCID: https://orcid.org/0000-0002-2114-2740)
- K Dever
- Peter Ermis
- Mallory Gahm
- Beryl C. Zhuang
Institutions
- Northwestern University (US)
- University of British Columbia (CA)
- Baylor College of Medicine (US)
- Southwestern Medical Center (US)
- Texas Children's Hospital (US)
- BC Children's Hospital (CA)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-02-15
- DOI
- https://doi.org/10.1186/s13148-026-02049-5
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00