Invasomal Nanocarrier Drug Delivery System for Enhanced Transdermal Application

Abstract: The transdermal approach is a useful method for achieving localised or systemic effects. The use of nanocarrier-based drug delivery systems has seen a positive transformation, especially when it comes to the non-invasive method of medication delivery via the skin. It enhances the penetrant properties of vital drugs and bioactive candidates. Invasomes are nano-sized vesicular structures that elevate skin penetration by disturbing the lipids of the epidermis, interacting with matrix proteins, and enhancing the partitioning of the drug molecule in the skin layer. Invasomes have a great potential for penetration due to their penetrative stimulants, terpene, and ethanol. A lot of benefits are offered by invasomes, such as increased comfort and compliance from patients and improved medication efficacy. Unlike liposomal vesicles, invasomes are newly engineered liposomes composed of volatile oil molecules. Additionally, ethanol can be found in the compartments in trace amounts in both the hydrous centre and the fatty shell. Effective research and development are necessary for the medication to be transported to the skin, one of the primary and most vital organs in the human body. Though the outer layer of skin is considered a multifunctional organ of the human body, transmission through the skin is limited by the stratum corneum (SC). Many carrier platforms have been formulated to overcome this barrier, which has a significant impact on the active agent. The paper elaborates on invasomes, their structure, invasion mechanism, and applications in drug delivery.