Colon-targeted microbiota-modulating nanoparticles amplify azathioprine efficacy via gut microbiota axis remodeling in inflammatory bowel disease
In summary, our findings indicate that APZE and Bifidobacterium improved intestinal barrier repair and colitis-related outcomes in a DSS-induced model, supporting their potential as therapeutic agents for IBD.
Authors
- Jiaqi Han (ORCID: https://orcid.org/0009-0008-4826-7210)
- Bing Hao (ORCID: https://orcid.org/0000-0003-3029-5340)
- Yubin He (ORCID: https://orcid.org/0000-0002-3434-4595)
- Libo Zhao (ORCID: https://orcid.org/0000-0002-4968-6045)
- Dong Mei (ORCID: https://orcid.org/0000-0002-0801-8702)
- Xiangyu Ma
- Xiao Lu
- Luquan Wang
- Jingjing Zhang
- Yanni Zhang
- Siyao Jin
- Yana Li
Institutions
- China Pharmaceutical University (CN)
- Capital Medical University (CN)
- Peking University (CN)
- Peking University Third Hospital (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-02-15
- DOI
- https://doi.org/10.1186/s12951-026-04136-4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00